Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
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To evaluate differences among patients with different clinical features of ALS, we used our Bayesian method of motor unit number estimation (MUNE). ⋯ These findings could indicate differences in disease pathogenesis.
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Comparative Study
Representation of cricothyroid muscles at the primary motor cortex (M1) in healthy subjects, mapped by navigated transcranial magnetic stimulation (nTMS).
To establish a methodology for mapping of primary motor cortex (M1) for cricothyroid (CTHY) muscles in a group of healthy subjects using three-dimensional (3D) magnetic resonance imaging (MRI) navigated transcranial magnetic stimulation (nTMS). ⋯ Mapping of M1 for CTHY muscle might represent an important neurophysiologic marker for facilitating preoperative mapping of motor speech-related cortical areas due to the proximity of motor cortical representation for laryngeal muscles and opercular part of the Broca area.
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Essential tremor (ET) is characterized by an action tremor believed to be due to excessive theta-alpha activity in the cerebello-thalamo-cortical system. This study aimed to test the hypothesis that therapeutic thalamic stimulation in patients with ET decreases theta-alpha oscillatory activity in primary motor (M1) and sensory (S1) cortices. ⋯ We demonstrate that ECoG can be effectively used to study the effect of subcortical stimulation on cortical oscillations.
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To use our Bayesian method of motor unit number estimation (MUNE) to evaluate lower motor neuron degeneration in ALS. ⋯ This shows that the Bayesian MUNE method is useful in following the course and exploring the clinical features of ALS.
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To investigate the P18 component in the posterior to anterior neck montage after median nerve stimulation. ⋯ Studying this component may add to the knowledge of the function of the spinal cord in humans.