Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
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To evaluate the functional activation of the somatosensory cortical regions in neuropathic pain patients during therapeutic spinal cord stimulation (SCS). ⋯ Results suggest that the effects of SCS on cortical somatosensory processing may contribute to a reduction of allodynia during SCS.
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Clinical Trial
Effect of theta burst stimulation over the human sensorimotor cortex on motor and somatosensory evoked potentials.
To study the after-effect of theta burst stimulation (TBS) over the left sensorimotor cortex on the size of somatosensory as well as motor evoked potentials evoked from both hemispheres in healthy human subjects. ⋯ TBS is an interventional tool that can induce rapid reorganization within cortical somatosensory as well as motor networks in humans.
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Randomized Controlled Trial
The after-effect of human theta burst stimulation is NMDA receptor dependent.
To provide pharmacological evidence that the after-effects of theta burst stimulation (TBS) involve plasticity like changes in cortical synaptic connections, using the N-methyl-D-aspartate receptor antagonist memantine. ⋯ The NMDA dependency of the after-effects of TBS adds to the understanding of the underlying mechanism of TBS, and suggests that these after-effects are likely to involve plasticity like changes at synaptic connections in motor cortex.
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Randomized Controlled Trial
Effect of low-level clenching and subsequent muscle pain on exteroceptive suppression and resting muscle activity in human jaw muscles.
To investigate the effects of muscle fatigue induced by low-level isometric jaw-clenching and subsequent glutamate-evoked muscle pain on the exteroceptive suppression (ES) response and resting electromyographic (EMG) activities in human jaw muscles. ⋯ Muscle fatigue which can be observed in patients with oral dysfunctions may interact with nociceptive regulation and influence the clinical presentation of jaw symptoms and function.
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To investigate the possible presence of multiple spino-thalamic pathways with different conduction velocities (CVs) in the human spinal cord. ⋯ Both the N1 and P2 potentials should be recorded in the clinical routine since a dissociated abnormality of either response may be found in lesions of the nociceptive system not only in the brain, but also at spinal cord level.