Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
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Zhonghua Yu Fang Yi Xue Za Zhi · Jul 2009
[Effects of perfluorooctane sulfonate on learning and memory of rat pups].
To study the effects of prenatal and postnatal perfluorooctane sulfonate (PFOS) exposure on spatial learning and memory, N-methyl-D-aspartate receptor 2B (NR2B) mRNA and protein level in frontal cortex and hippocampus of rat pups and to explore the mechanism of developmental neurotoxicity induced by PFOS. ⋯ Prenatal and postnatal exposure to PFOS should result in the spatial learning and memory damage,and the mechanism might be possibly involved in the decrease of NR2B level in cerebral cortex and hippocampal formation regions.