Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
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Saudi J Kidney Dis Transpl · Jul 2011
Comparative StudySodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) of urinary protein in acute kidney injury.
Recent experimental and clinical studies have shown the importance of urinary proteomics in acute kidney injury (AKI). We analyzed the protein in urine of patients with clinical AKI using sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) for its diagnostic value, and followed them up for 40 months to evaluate prognosis. Urine from 31 consecutive cases of AKI was analyzed with SDS-PAGE to determine the low, middle and high molecular weight proteins. ⋯ Tubular protein was common in the study cases with CRF, DM and cases without hematuria. This indicates tubulo-interstitial injury for AKI in these cases. Patients with predominantly glomerular protein had an adverse outcome.
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Saudi J Kidney Dis Transpl · Jul 2011
Comparative StudyAcute kidney injury in a teaching hospital in Oman.
To determine the incidence, etiology and outcome of acute kidney injury (AKI) at a teaching hospital in Oman, we studied all adult cases that developed AKI at our hospital from July 2006 to June 2007. Data from the hospital information system (HIS) for all adult admissions in the wards and intensive care units for the study period were obtained, and included baseline serum creatinine, serum creatinine on the day of diagnosis, peak serum creatinine, urine output in the last six and 12 hours at the time of diagnosis, etiology of acute renal failure, presence of any co-morbid conditions, and renal replacement therapy and outcome. Of the 19,738 adult admissions, there were 108 episodes of AKI in 100 patients. ⋯ The etiology of AKI was pre-renal in 55 (50.9%), obstructive in 5 (4.6%) and acute tubular necrosis (ATN) in the remaining 48 (44.4%) patients. Renal replacement therapy (RRT) was required in 24.1% of cases. Of the patients who developed AKI, 36 (33.33%) died during same hospital admission, 37 (34.26%) recovered to discharge with no renal impairment, 32 (29.63%) recovered with residual renal impairment and 2 (1.85%) recovered with dialysis dependence.