Farmakologiia i toksikologiia
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Comparative Study
[Evaluation of the pharmacological properties of a new steroid curarelike agent, RGH 1106].
Tests on cats showed the compound RGH 1106 to possess an antidepolarizing mechanism of action. The sequence of myorelaxation, arising under the effect of this agent, is characterized by relaxation in the first place of the musculus masseter, muscles of limbs, then of abdominal muscles and those of the diaphragm and, finally, of the intercostal muscles. RGH 1106 doses not possess cardiotropic m-cholinolytic action, does not exert a ganglion blocking effect, nor affects the central nervous system. It neither changes the blood supply of the myocardium and the uptake of oxygen by the latter, nor inhibits the acetylcholinesterase.
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Comparative Study
[Effect adrenaline and ephedrine against a background of aminazine on systemic, cerebral and extracerebral hemodynamics].
Experiments with anesthetized cats demonstrated chlorpromazine (2 mg/kg) to pervert the vasopressor action of adrenaline (5 mkg/kg) and ephedrine (2 mg/kg) on the systemic arterial pressure, cerebral and extracerebral tonicity of the vessels. The authors believe that with chlorpromazine pretreatment the adrenomimetics produce a selective stimulation of the beta-adrenergic receptors, this accounting for the observed depressor effect.
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Comparative Study
[Relationship between the pain-relieving action of narcotic analgesics and their effect on respiration].
Experiments with rabbits (30) and albino rats (110) demonstrated that morphine (1 mg/kg), promedol (trimeperidine) (2 mg/kg) and phentanyl (0.02 mg/kg), while raising by 21-24 per cent of the algesia threshold, produced an analgesic effect differeing in its duration (morphine-130 min, trimeperidine-70 min, phentanyl-17 min). This is attended by changes in respiration (greater on introduction of phentanyl, and lesser, following administration of morphine) and by shifts in the functional state of the tissues (greater on introduction of trimeperidine and lesser after aministration of morphine).
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The influence of pyridinolcarbamate (parmidine) on raising the tonicity of bronchial and intestinal muscles in guinea pigs, and also on the edema of the paw in rats, induced with bradykinin was studied. Parmidin displays a specific antibradykinin activity and mitigates the effects of bradykinin in all the objects under investigation, without exercising any influence on the spasmogenic action of histamine, serotonin and acetylcholine.