Diabetes technology & therapeutics
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Diabetes Technol. Ther. · May 2010
Clinical TrialHospital glucose control: safe and reliable glycemic control using enhanced model predictive control algorithm in medical intensive care unit patients.
The aim of this study was to investigate the performance of the enhanced Model Predictive Control (eMPC) algorithm for glycemic control in medical critically ill patients for the whole length of intensive care unit (ICU) stay. ⋯ In our single-center, noncontrolled study the eMPC algorithm was a safe and reliable method to control BG in critically medical ICU patients for the whole length of ICU stay.
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Diabetes Technol. Ther. · Apr 2010
Insulin pump therapy in Moslem patients with type 1 diabetes during Ramadan fasting: an observational report.
Many Moslem patients do observe the fast during Ramadan. There are limited data on insulin pump therapy during Ramadan. We report our experience with type 1 diabetes patients on insulin pumps during Ramadan 2008 (29 days). ⋯ Fasting during Ramadan is feasible in patients with type 1 diabetes using an insulin pump, with adequate counseling and support.
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Diabetes Technol. Ther. · Apr 2010
Glucose monitoring by means of an intravenous microdialysis catheter technique.
Patients with acute coronary syndrome (ACS) and hyperglycemia are at an increased mortality risk. A rapidly obtained optimized glycemic control without inducing hypoglycemia is important. We evaluated the accuracy of a microdialysis catheter (CMA 64 IView, CMA Microdialysis AB, Solna, Sweden) to monitor glucose levels in patients in the coronary care unit (CCU). ⋯ These initial experiences are promising and motivate further research to improve the microdialysis technique. In future studies longer periods of recordings should be included to disclose technical problems.
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Diabetes Technol. Ther. · May 2009
Effect of steel and teflon infusion catheters on subcutaneous adipose tissue blood flow and infusion counter pressure in humans.
Subcutaneous tissue is an important target for drug deposition or infusion. A local trauma may induce alterations in local microcirculation and diffusion barriers with consequences for drug bioavailability. We examined the influence of infusion catheters' wear time on local microcirculation and infusion counter pressure. ⋯ ATBF and bolus mean infusion pressure increased significantly with a wear time of 48 h in Teflon but not in steel catheters. The maximal pressure required to deliver a bolus infusion increased with wear time of a catheter. A higher maximal pressure was required to deliver a bolus infusion through a Teflon than through a steel catheter. We propose that the difference in infusion counter pressure and ATBF between Teflon and steel catheters with wear time may be explained by better biocompatibility of steel than Teflon.
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Diabetes Technol. Ther. · Mar 2009
Randomized Controlled Trial Multicenter StudyA comparison of insulin injection needles on patients' perceptions of pain, handling, and acceptability: a randomized, open-label, crossover study in subjects with diabetes.
For some diabetes patients, subcutaneous injections are associated with pain, discomfort, and anxiety. We compared overall preferences of two needle types: NovoFine((R)) 32-gauge tip x 6 mm and NovoFine 30-gauge x 8 mm, when used with the FlexPen((R)) injection device (all from Novo Nordisk A/S [Copenhagen, Denmark] and Novo Nordisk Ltd. [Crawley, UK]). ⋯ NovoFine 32-gauge tip x 6 mm needles are a viable alternative to NovoFine 30-gauge tip x 8 mm needles for people administering daily insulin injections.