Fukuoka igaku zasshi = Hukuoka acta medica
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Fukuoka Igaku Zasshi · Dec 1993
[Experimental studies on the effect of heating on blood flow in the tongue of golden hamsters].
The effect of hyperthermia on the tongue of hamsters was evaluated histologically and by measuring blood flow. The dorsal tongue surface of the male mature golden hamster was heated at 41 degrees C-45 degrees C (surface temperature) by 2450 MHz microwave for 60 min, and the regional blood flow was measured using the hydrogen clearance method at 6, 24, 42, and 60 min during heating. When heated at 41 degrees C (9 animals), 42 degrees C (11 animals), 43 degrees C (8 animals), 44 degrees C (8 animals), or 45 degrees C (8 animals), the temperature of the measurement at 0.5 mm deep from the tongue surface was 38.4 +/- 1.0 degrees C, 39.3 +/- 0.6 degrees C, 40.2 +/- 0.6 degrees C, 40.8 +/- 0.5 degrees C, or 43.5 +/- 1.0 degrees C (Mean +/- S. ⋯ Additionally, thromboses were found in the group heated at 45 degrees C which was examined 2 hours after heating. The heated part was necrosed in every case heated at 45 degrees C. These results suggest that the critical surface temperature at which the tongue of hamsters receive irreversible damage lies between 44 degrees C and 45 degrees C.