Fiziologicheskiĭ zhurnal
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Fiziologicheskiĭ zhurnal · Jan 2008
[Cardioprotective effects of flokalin: relative role of activation of sarcolemmal and mitochondrial adenosine triphosphate-dependent potassium channels].
In experiments on isolated Langendorff perfused hearts of guinea pig with modeling of ischemia (20 min) and reperfusion (40 min) the cardioprotective effects of flokalin were shown. Preliminary preischemic perfusion of isolated heart with flokalin (5 mM) for 5 minutes has significantly improved the recovery of contractive function ofischemic myocardium at repcrfusion. Particularly, recovery of systolic and developed pressure was improved and the increasing of end-diastolic pressure in left ventricle was prevented. ⋯ The intact structure of mitochondria also was saved by flokalin that maintains the energy potential of myocardium. Using the selective blocker of mitochondrial K(ATP) channels 5-hydroxydecanoate (200 mM) allows to determine the relative role of sarcolemmal and mitochondrial K(ATP) channels activation in these effects. It was shown that mitochondrial as well as sarcolemmal K(ATP) channels play role in the recovery of ischemic myocardium functions: first are responsible for recovery of contractive function and second are responsible for coronary blood flow recovery.
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Fiziologicheskiĭ zhurnal · Jan 2008
Review[Some conceptual aspects in studies of the autonomic nervous system].
As a result of intensive research performed in different laboratories recent years in the field of autonomic nervous system physiology, considerable experimental material was collected and some new and interesting hypotheses were proposed. This review is a short sketch about the progress in the study of autonomic transmission mechanisms. Since the sixties of the last century non-adrenergic non-cholinergic nerves were opened, and it was the later recognition of a multiplicity of neurotransmitter substances in autonomic nerves. ⋯ The article describes the types of synaptic interaction of the autonomic nervous system neurons by the example of sympathetic neurons of the superior cervical ganglion and plasticity of the neurons of this ganglia grown in culture conditions in relation to the expression ofadrenergic and cholinergic properties as well as the role of the calcium ions in regulation of cellular processes. Studies of the last few decades have given impetus for elaboration of new concepts of autonomic nervous system function, part of which is represented in this review. The prospects for further investigations are described.