Fiziologicheskiĭ zhurnal
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Fiziologicheskiĭ zhurnal · Jan 2016
[CORRECTION OF HEART RATE VARIABILITY USING DIAPHRAGMATIC BREATHING MODE BIOFEEDBACK IN HEALTHY PEOPLE.]
The research is an attempt to explain the use of portable computer devices aiming to correct heart rate variability (HRV) of healthy young men. According to the data, used deep diaphragmatic breathing in mode of biofeedback harmonizes breathing and blood circulation which positively affects the body's adaptive potential. However, developers present the portable instruments of biofeedback primarily as a means of psychological relaxation. ⋯ This means that activity redistribution between different regulatory components of heart rate occurred in favour of the peripheral ANS parts. Heart rate variability changes of this kind remained valid for at least one month after the experiment. The greatest influence on heart rate variability was observed in the group of people who used the device StressEraser.
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Fiziologicheskiĭ zhurnal · Jan 2012
[Study of the impact of omega-3 PUFA on fatty acid composition of heart, respiration and swelling of mitochondria of the heart in diabetes].
We studied the influence of omega-3 polyunsaturated fatty acids (PUFAs) on respiration, swelling of rat heart mitochondria and changes in rat heart fatty acid composition in tissue homogenate in rats with streptozotocin induced diabetes mellitus (diabetes), which was induced by single intraperitoneal administration of 55 mg/kg streptozotocin. We found that application of these acids increased parameters of active mitochondrial respiration V3 at 63.7%, controlled breathing V4 at 30.7% and the rate of phosphorylation by 18.9% in animals with experimental diabetes. ⋯ In addition, we established changes of fatty acid composition of cell membranes in hearts under diabetic conditions with omega-3 PUFAs influence. The obtained results allow to conclude that the omega-3 PUFA have a positive effect on functional parameters of mitochondria due to stabilization cell membranes of rat heart with diabetes.
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Fiziologicheskiĭ zhurnal · Jan 2010
[Effect of long-term monosodium glutamate administration on structure and functional state of the stomach and body weight in rats].
The influence of prolonged administration of monosodium glutamate (MSG) on basal gastric acid secretion, body weight and gastric mucosa in rats was studied. We found that 10-, 20-, 30-days feeding by MSG in doses 15 to 30 mg/kg (equivalent to I and 2 g/person) leads to erosive and ulcerative lesions of the gastric mucosa and an increased secretion of hydrochloric acid and an increased body weight. ⋯ Therefore, the maximum dose of MSG should be reconsidered taking into account its influence on the secretory capacity of the stomach. We also conclude that prolonged, excessive and systemic consumption of MSG causes obesity.
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Fiziologicheskiĭ zhurnal · Jan 2008
[Cardioprotective effects of flokalin: relative role of activation of sarcolemmal and mitochondrial adenosine triphosphate-dependent potassium channels].
In experiments on isolated Langendorff perfused hearts of guinea pig with modeling of ischemia (20 min) and reperfusion (40 min) the cardioprotective effects of flokalin were shown. Preliminary preischemic perfusion of isolated heart with flokalin (5 mM) for 5 minutes has significantly improved the recovery of contractive function ofischemic myocardium at repcrfusion. Particularly, recovery of systolic and developed pressure was improved and the increasing of end-diastolic pressure in left ventricle was prevented. ⋯ The intact structure of mitochondria also was saved by flokalin that maintains the energy potential of myocardium. Using the selective blocker of mitochondrial K(ATP) channels 5-hydroxydecanoate (200 mM) allows to determine the relative role of sarcolemmal and mitochondrial K(ATP) channels activation in these effects. It was shown that mitochondrial as well as sarcolemmal K(ATP) channels play role in the recovery of ischemic myocardium functions: first are responsible for recovery of contractive function and second are responsible for coronary blood flow recovery.
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Fiziologicheskiĭ zhurnal · Jan 2008
Review[Some conceptual aspects in studies of the autonomic nervous system].
As a result of intensive research performed in different laboratories recent years in the field of autonomic nervous system physiology, considerable experimental material was collected and some new and interesting hypotheses were proposed. This review is a short sketch about the progress in the study of autonomic transmission mechanisms. Since the sixties of the last century non-adrenergic non-cholinergic nerves were opened, and it was the later recognition of a multiplicity of neurotransmitter substances in autonomic nerves. ⋯ The article describes the types of synaptic interaction of the autonomic nervous system neurons by the example of sympathetic neurons of the superior cervical ganglion and plasticity of the neurons of this ganglia grown in culture conditions in relation to the expression ofadrenergic and cholinergic properties as well as the role of the calcium ions in regulation of cellular processes. Studies of the last few decades have given impetus for elaboration of new concepts of autonomic nervous system function, part of which is represented in this review. The prospects for further investigations are described.