Fiziologicheskiĭ zhurnal
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Fiziologicheskiĭ zhurnal · Jan 2010
[Effect of long-term monosodium glutamate administration on structure and functional state of the stomach and body weight in rats].
The influence of prolonged administration of monosodium glutamate (MSG) on basal gastric acid secretion, body weight and gastric mucosa in rats was studied. We found that 10-, 20-, 30-days feeding by MSG in doses 15 to 30 mg/kg (equivalent to I and 2 g/person) leads to erosive and ulcerative lesions of the gastric mucosa and an increased secretion of hydrochloric acid and an increased body weight. ⋯ Therefore, the maximum dose of MSG should be reconsidered taking into account its influence on the secretory capacity of the stomach. We also conclude that prolonged, excessive and systemic consumption of MSG causes obesity.