Developmental medicine and child neurology
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Dev Med Child Neurol · Oct 2014
Comparative StudyEstimation of length or height in infants and young children using ulnar and lower leg length with dual-energy X-ray absorptiometry validation.
We compared the accuracy and reproducibility of using ulnar and lower leg length measurements to predict length and height in infants and children aged 0 to 6 years. ⋯ Length and height measurements using infant length board or stadiometer are reproducible. Because of the wide limits of agreement, estimation of length and height in children using ulnar and lower leg length is not an acceptable alternative to traditional methods.
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Dev Med Child Neurol · Aug 2014
Comparative StudyDiffusion tensor imaging in pediatric Chiari type I malformation.
Chiari type I malformation (C1M) may be symptomatic or asymptomatic as an incidental finding. In this retrospective study, we applied diffusion tensor imaging (DTI) to study the brainstem and cerebellar white matter tracts in C1M. ⋯ Our results show that microstructural tissue alterations may be present in C1M. Additionally, our study suggests a specific role for the MCPs in C1M. Further large-scale studies are warranted.
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Dev Med Child Neurol · Jul 2014
Benign hereditary chorea related to NKX2.1: expansion of the genotypic and phenotypic spectrum.
Benign hereditary chorea is a dominantly inherited, childhood-onset hyperkinetic movement disorder characterized by non-progressive chorea and variable degrees of thyroid and respiratory involvement. Loss-of-function mutations in NKX2.1, a gene vital to the normal development and function of the brain, lungs, and thyroid, have been identified in a number of individuals. ⋯ Our data suggest that the neurological phenotype is prominent in this condition and that many patients with benign hereditary chorea do not have the classic triad of brain-lung-thyroid syndrome. The extended phenotype may include obsessive-compulsive disorder and skeletal abnormalities.