Archives of oral biology
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Archives of oral biology · Apr 2012
Antibacterial activity of povidone-iodine against an artificial biofilm of Porphyromonas gingivalis and Fusobacterium nucleatum.
To investigate the antibacterial activity of povidone-iodine (PVP-I) on an artificial dual species biofilm of periodontal pathogens. ⋯ These results suggest that 30s application of 2% PVP-I would be effective in suppressing both P. gingivalis and F. nucleatum in dual-species biofilm, and this provides clinical implication for the control of subgingival biofilm.
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Archives of oral biology · Apr 2012
Invadopodia formation in oral squamous cell carcinoma: the role of epidermal growth factor receptor signalling.
Invadopodia are actin-rich structures that are formed on the ventral membrane of the cell and degrade extracellular matrix (ECM) by accumulation of matrix metalloproteinase (MMP). Consequently, understanding how invadopodia form and function should facilitate the identification of new therapeutic target for anti-invadopodia therapy. The present study was designed to investigate invadopodia formation associated with oral squamous cell carcinoma (OSCC) and the effect of epidermal growth factor receptor (EGFR) signalling on invadopodia formation and ECM degradation activity. ⋯ We provide evidence that HSC-3 OSCC has a tendency to adopt invadopodia for invasion and accompanying MMP-dependent proteolytic ECM degradation and EGFR signalling is necessary for invadopodia formation and associated ECM degradation activity.