Archives of oral biology
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Archives of oral biology · Sep 2015
Synovial TRPV1 is upregulated by 17-β-estradiol and involved in allodynia of inflamed temporomandibular joints in female rats.
Women with reproductive capability are more likely to suffer from temporomandibular disorders (TMD), with orofacial pain as the most common complaint. In the past, we focused on the role of estradiol in TMD pain through the nervous system. In this study, we explored estradiol's influence on synoviocyte gene expressions involved in the allodynia of the inflamed TMJ. ⋯ Moreover, intra-TMJ injection of TRPV1 antagonist, capsazepine, significantly attenuated allodynia of the inflamed TMJ induced by intra-TMJ injection of CFA in female rats. This article presents a possible local mechanism for estradiol that may be involved in TMJ inflammation or pain in the synovial membrane through the pain-related gene TRPV1. This finding could potentially help clinicians understand the sexual dimorphism of TMD pain.
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Archives of oral biology · Jul 2015
Effect of topical anaesthesia in patients with persistent dentoalveolar pain disorders: A quantitative sensory testing evaluation.
The aim of this study was to test the hypothesis that patients with persistent dentoalveolar pain disorder (PDAP) expresses somatosensory abnormalities through quantitative sensory testing (QST), when compared to healthy controls; and that individuals with PDAP do not have somatosensory alterations after application of a topical anaesthetic gel. ⋯ PDAP patients had abnormal thermal sensory and mechanical allodynia, which is indicative of central sensitization. Moreover, topical anaesthetic incited a significant reduction in pain intensity, and an increase in mechanical and pain detection thresholds, which could be also suggestive of a peripheral disorder.
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Archives of oral biology · May 2015
Randomized Controlled TrialAdditional effect of occlusal splints on the improvement of psychological aspects in temporomandibular disorder subjects: A randomized controlled trial.
To measure the effect of occlusal splints as an additional treatment on psychological aspects in temporomandibular disorder patients. ⋯ Minimally invasive strategies could provide an improvement in the psychological aspects of temporomandibular disorder patients, and the use of an occlusal splint seems to hasten the manifestation of these effects.
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Archives of oral biology · May 2015
Neck disability is associated with masticatory myofascial pain and regional muscle sensitivity.
The primary aims of this study are to compare neck disability in masticatory myofascial pain subjects versus asymptomatic controls, and to evaluate the correlation between neck disability and muscle pain. ⋯ Our results reinforced the clinical interconnection between masticatory and cervical structures, insofar as subjects with masticatory myofascial pain reported greater neck disability, which, in turn, was correlated with regional muscle sensitivity.
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Archives of oral biology · Mar 2015
Lithium inhibits palatal fusion and osteogenic differentiation in palatal shelves in vitro.
Glycogen synthase kinase-3β (Gsk-3β)/β-catenin signaling regulates development of the secondary palate. It has been unclear about the effects of Gsk-3β/β-catenin signaling on palatal fusion and osteogenic differentiation in palatal shelves. ⋯ Our findings show that LiCl-mediated GSK3β inhibition prevents palatal fusion and osteogenic differentiation in palatal shelves by increased β-catenin signaling. It indicated that overactivation of canonical Wnt signaling might impair the fusion of the secondary palate.