Archives of oral biology
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Archives of oral biology · Feb 2015
Effect of experimental jaw muscle pain on dynamic bite force during mastication.
Knowledge about how Temporomandibular Disorder (TMD) pain patients regulate masticatory function is still unclear. To investigate the effect of experimental jaw muscle pain as well as texture and size of food on mastication, twelve healthy participants (30.6±7.5 years old) participated in this study. Experimental pain was induced by an infusion of 0.5 M monosodium glutamate (MSG) with isotonic saline (IS) serving as a control. ⋯ On the other hand, the results suggested that the applied levels of pain may not change habitual masticatory movements. This study has revealed that a clinically relevant level of pain in the masseter muscle has only minor impact on the performance of mastication, probably due to a lack of exacerbation of pain during function. In future studies of jaw muscle function during painful conditions, it is important to include patient-based reports of functional limitation and emotional distress.
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Archives of oral biology · Dec 2014
Optimization of jaw muscle activity and fine motor control during repeated biting tasks.
To investigate if repeated holding and splitting of food morsel change the variability of force and jaw muscle activity in participants with natural dentition. ⋯ There was no evident optimization of jaw motor function in terms of reduction in the variability of bite force values and muscle activity, when this simple task was repeated up to sixty times in participants with normal intact periodontium.
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Archives of oral biology · Jul 2014
Up-regulation of PKMζ expression in the anterior cingulate cortex following experimental tooth movement in rats.
To explore the involvement of synaptic plasticity in pain induced by experimental tooth movement, we evaluated the expression of protein kinase M zeta (PKMζ), an enzyme necessary for maintaining long-term potentiation (LTP) in the anterior cingulate cortex (ACC). ⋯ PKMζ in the ACC acts to maintain the pain induced by experimental tooth movement. Increased expression of PKMζ protein is attributed to persistent translation of PKMζ mRNA. Synaptic plasticity may be involved in the development of tooth movement pain.
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Archives of oral biology · Jun 2014
Hypoxia-inducible factor-1α is required for transforming growth factor-β1-induced type I collagen, periostin and α-smooth muscle actin expression in human periodontal ligament cells.
We reported previously that hypoxia inducible factor (HIF)-1α was not degraded under normoxic condition with transforming growth factor (TGF)-β1 stimulation in human periodontal ligament (PDL) cells; however, the role of HIF-1α has been unclear. Recently, HIF-1α, working together with TGF-β1, has been reported to promote extracellular matrix accumulation under normoxic condition in renal epithelial cell. The aim of this study is to investigate the effects of HIF-1α on the expression of TGF-β1-mediated genes including type I collagen, periostin and α-smooth muscle actin (SMA) in human PDL cells. ⋯ HIF-1α is required for TGF-β1-induced type I collagen, periostin and α-SMA expression in human PDL cells.
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Archives of oral biology · May 2014
Randomized Controlled Trial Comparative StudyComparison of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF) in rabbit-skull defect healing.
The objective of this study was to evaluate the effect of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF) on bone healing. ⋯ The addition of PRP, PRF, and CGF had significantly increased bone formation at the 6th week. The effect of PRP, PRF, and CGF was similar and may be useful in the future to increase the success rate of bone grafting.