Arquivos de neuro-psiquiatria
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Review Meta Analysis
Transcutaneous vagus and trigeminal nerve stimulation for neuropsychiatric disorders: a systematic review.
We reviewed trigeminal nerve stimulation (TNS) and transcutaneous vagus nerve stimulation (tVNS). All techniques have shown preliminary promising results, although the results are mixed. ⋯ TNS and tVNS improve treatment of particular neuropsychiatric disorders such as depression.
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Review Meta Analysis
Beta interferons in clinically isolated syndromes: a meta-analysis.
Beta-interferon use in definite multiple sclerosis (MS) has been proven to modify clinical and magnetic resonance imaging outcome. We review and summarize the data of published double-blind, randomized clinical trials to assess, with a meta-analysis the safety and efficacy of beta-interferon on the occurrence of relapses in patients with a first clinical event suggestive of MS. ⋯ Side-effects were mild and self limited. Our findings support the efficacy of early treatment with beta-interferon in reducing conversion to clinically defined MS in patients with clinically isolated syndromes.
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Meta Analysis
Botulinum toxin type A for the treatment of the upper limb spasticity after stroke: a meta-analysis.
Muscle over-activity is one of the cardinal features of spasticity and it is a common disability of stroke patients. In this group, spasticity is responsible for several limitations that interfere in their daily activities and quality of life. ⋯ In this article we summarize the data of previous double-blind, randomised clinical trials to asses, with a meta-analysis, if BTX-A is an adequate treatment for spasticity due to stroke. The results show a statistical superiority of BTX-A ov%r placebo on reducing muscle tone by the Modified Ashworth Scale (WMD= 0.95 [0.74 to 1.17]) in patients with post-stroke upper limb spasticity.