Articles: analgesics.
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Int J Clin Pharmacol Ther Toxicol · Sep 1984
Comparative Study Clinical TrialDezocine for postoperative wound pain.
We assessed the analgesic effectiveness of a single intramuscular injection of dezocine, 10 mg or 15 mg; morphine, 10 mg; or a placebo in 160 patients with moderate to severe postoperative pain. Dezocine, 10 mg, was as effective as and had approximately the same duration of action as morphine, 10 mg. ⋯ A small percentage of patients suffered nausea and became sedated; the drugs and placebo, however, did not differ statistically with respect to the side effects. Blood pressure, heart rate, and respiratory rate generally were slightly decreased by both drugs.
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Randomized Controlled Trial Comparative Study Clinical Trial
Alfentanil in minor gynaecological surgery: use with etomidate and a comparison with halothane.
Etomidate was used to induce anaesthesia in 50 healthy subjects undergoing minor gynaecological surgery who were randomly divided into two groups, one receiving alfentanil 8 micrograms/kg intravenously immediately prior to induction of anaesthesia with etomidate, and the other halothane as required to maintain adequate anaesthesia. There was a highly significant reduction in the incidence of myoclonia and involuntary movement and significant reduction of pain on injection in the alfentanil group. Tests of recovery performed in the 60 minutes following anaesthesia suggested that supplementation with alfentanil led to more rapid recovery than halothane.