Articles: postoperative-pain.
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Randomized Controlled Trial Comparative Study Clinical Trial
Double-blind evaluation of buprenorphine hydrochloride for post-operative pain.
In a double-blind, random assignment study of four groups of 40 patients, relief of severe pain with buprenorphine hydrochloride 0.2 mg or 0.4 mg was evaluated and compared with morphine sulphate 5 or 10 mg. Evaluations included pain intensity, pain relief, sedation and other effects for up to 12 hours after drug administration, following recovery of wakefulness from anaesthesia for major abdominal surgery. Analyses of five parameters showed that the four groups were statistically comparable and that buprenorphine hydrochloride is at least 50 times more potent than morphine sulphate and has a substantially longer duration of analgesic action. Further clinical evaluation is, therefore, recommended.
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Comparative Study Clinical Trial Controlled Clinical Trial
Postoperative analgesia with ketamine and pethidine.
A double-blind trial compared ketamine with pethidine, pethidine alone at two dose levels and a placebo, in patients with postoperative pain. By assessment of pain intensity, observed relief and side-effects, the active drugs were clearly distinguishable from the placebo. With the doses used, however, the combination of ketamine with pethidine showed no advantage over pethidine alone.
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Randomized Controlled Trial Comparative Study Clinical Trial
Anidoxime: a clinical trial of an oral analgesic agent.
The new oral analgesic drug anidoxime was compared with dihydrocodeine. There were no side-effects, and no significant differences between the effects of dihydrocodeine 50 mg, anidoxime 75 mg or anidoxime 100 mg.
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Arch. Immunol. Ther. Exp. (Warsz.) · Jan 1977
Comparative Study Clinical Trial Controlled Clinical TrialA double-blind comparative evaluation of aspirin, paracetamol and paracetamol + caffeine (finimal) for their analgesic effectiveness.
A double-blind, cross-over trial was made of three analgesic preparations--paracetamol, paracetamol with caffeine (Finimal) and aspirin in the relief of postoperative pain in 72 orthopedic inpatients and in 144 ambulatory outpatients suffering form common idiopathic headache. The combination of paracetamol and caffeine (Finimal) in this study shows the greatest pain relief in both groups of patients. This evaluation supports the results of BOOY3 demonstrating the superiority of the paracetamol-caffeine combination to paracetamol alone or aspirin.
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Comparative Study Clinical Trial Controlled Clinical Trial
Pain relief in the post-operative period: a comparative trial of morphine and a new analgesic buprenorphine.
In a comparative trial, buprenorphine 0-3 mg or morphine 10 mg was administered intramuscularly to patients post-operatively. The new drug buprenorphine produced more pain relief than morphine and appeared to have a longer duration of action. The side-effects produced by the two drugs were similar, as were the effect on respiratory and cardiovascular measurements.