Articles: coronavirus.
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The new SARS-CoV-2 virus enters cells via angiotensin-converting enzyme 2 (ACE2). ACE2 counteracts ACE and angiotensin II in the renin-angiotensin-aldosterone system (RAAS) and has critical functions in the lung and cardiovascular system. SARS-CoV was found to down-regulate ACE2, leaving angiotensin II unbalanced in affected organs. A similar effect of SARS-CoV-2 could partly explain risk factors and symptoms, and could potentially be treatable.
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Angiotensin converting enzyme 2 (ACE2) is the major enzyme responsible for conversion of Ang II into Ang-(1-7). It also acts as the receptor for severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2, which causes Coronavirus Disease (COVID)-19. In recognition of the importance of ACE2 and to celebrate 20 years since its discovery, the journal will publish a focused issue on the basic science and (patho)physiological role of this multifunctional protein.
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Case Reports
Extracorporeal Membrane Oxygenation as Treatment of Severe COVID-19 Infection: A Case Report.
Novel coronavirus 2019 (COVID-19) is a severe respiratory infection leading to acute respiratory distress syndrome (ARDS) accounting for thousands of cases and deaths across the world. Several alternatives in treatment options have been assessed and used in this patient population. ⋯ The use of VV-ECMO in COVID-19 infected patients is still controversial. While some studies have shown a high mortality rate despite aggressive treatment, such as in our case, the lack of large sample size studies and treatment alternatives places healthcare providers against a wall without options in patients with severe refractory ARDS due to COVID-19.
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Int J Environ Res Public Health · Apr 2020
Using Social Media to Mine and Analyze Public Opinion Related to COVID-19 in China.
The outbreak of Corona Virus Disease 2019 (COVID-19) is a grave global public health emergency. Nowadays, social media has become the main channel through which the public can obtain information and express their opinions and feelings. This study explored public opinion in the early stages of COVID-19 in China by analyzing Sina-Weibo (a Twitter-like microblogging system in China) texts in terms of space, time, and content. ⋯ It is suggested that the government should strengthen the response in terms of public opinion and epidemic prevention and exert control in key epidemic areas, urban agglomerations, and transboundary areas at the province level. In controlling the crisis, accurate response countermeasures should be formulated following public help demands. The findings can help government and emergency agencies to better understand the public opinion and sentiments towards COVID-19, to accelerate emergency responses, and to support post-disaster management.