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Created June 3, 2015, last updated almost 4 years ago.
Collection: 24, Score: 4437, Trend score: 0, Read count: 4855, Articles count: 8, Created: 2015-06-03 03:27:05 UTC. Updated: 2021-02-08 23:54:14 UTC.Notes
A growing collection of landmark papers relevant to intensive care and critical care medicine.
These papers are practice changing and hold current, ongoing significance beyond their historical importance.
This is a dynamic and changing document that will be updated, pruned and added to as appropriate. Many of these papers have free full-text provided by the publisher because of their significance.
Daniel Jolley
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Collected Articles
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network.
Traditional approaches to mechanical ventilation use tidal volumes of 10 to 15 ml per kilogram of body weight and may cause stretch-induced lung injury in patients with acute lung injury and the acute respiratory distress syndrome. We therefore conducted a trial to determine whether ventilation with lower tidal volumes would improve the clinical outcomes in these patients. ⋯ In patients with acute lung injury and the acute respiratory distress syndrome, mechanical ventilation with a lower tidal volume than is traditionally used results in decreased mortality and increases the number of days without ventilator use.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group.
To determine whether a restrictive strategy of red-cell transfusion and a liberal strategy produced equivalent results in critically ill patients, we compared the rates of death from all causes at 30 days and the severity of organ dysfunction. ⋯ A restrictive strategy of red-cell transfusion is at least as effective as and possibly superior to a liberal transfusion strategy in critically ill patients, with the possible exception of patients with acute myocardial infarction and unstable angina.
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Randomized Controlled Trial Clinical Trial
Early goal-directed therapy in the treatment of severe sepsis and septic shock.
Goal-directed therapy has been used for severe sepsis and septic shock in the intensive care unit. This approach involves adjustments of cardiac preload, afterload, and contractility to balance oxygen delivery with oxygen demand. The purpose of this study was to evaluate the efficacy of early goal-directed therapy before admission to the intensive care unit. ⋯ Early goal-directed therapy provides significant benefits with respect to outcome in patients with severe sepsis and septic shock.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial.
Magnesium sulphate halves the risk of eclampsia in pre-eclamptic pregnant women without significant adverse effect.
pearl -
Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
A comparison of albumin and saline for fluid resuscitation in the intensive care unit.
ICU resuscitation with either normal saline or 4% albumin results in similar outcomes, in the absence of traumatic brain injury.
pearl -
Randomized Controlled Trial Comparative Study Clinical Trial
Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia.
Cardiac arrest outside the hospital is common and has a poor outcome. Studies in laboratory animals suggest that hypothermia induced shortly after the restoration of spontaneous circulation may improve neurologic outcome, but there have been no conclusive studies in humans. In a randomized, controlled trial, we compared the effects of moderate hypothermia and normothermia in patients who remained unconscious after resuscitation from out-of-hospital cardiac arrest. ⋯ Our preliminary observations suggest that treatment with moderate hypothermia appears to improve outcomes in patients with coma after resuscitation from out-of-hospital cardiac arrest.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest.
Cardiac arrest with widespread cerebral ischemia frequently leads to severe neurologic impairment. We studied whether mild systemic hypothermia increases the rate of neurologic recovery after resuscitation from cardiac arrest due to ventricular fibrillation. ⋯ In patients who have been successfully resuscitated after cardiac arrest due to ventricular fibrillation, therapeutic mild hypothermia increased the rate of a favorable neurologic outcome and reduced mortality.
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Randomized Controlled Trial Multicenter Study Comparative Study
Saline or albumin for fluid resuscitation in patients with traumatic brain injury.
In traumatic brain injury resuscitation with albumin is associated with a higher mortality than resuscitation with saline.
pearl
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