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Chinese medical journal · Jan 2020
ReviewEndoplasmic reticulum stress and destruction of pancreatic β cells in type 1 diabetes.
- Zhao-Hui Cao, Zhuan Wu, Cong Hu, Min Zhang, Wu-Zhou Wang, and Xiao-Bo Hu.
- Department of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China.
- Chin. Med. J. 2020 Jan 5; 133 (1): 687368-73.
AbstractType 1 diabetes (T1D) results from dysfunction of pancreatic islets β cells. Recent studies supported that endoplasmic reticulum (ER) stress takes an important role in pancreatic β cell excessive loss, resulting in T1D. Here, we aimed to review the relationship between ER stress and T1D. Additionally, we also reviewed the potential mechanisms underlying ER stress mediated T1D. Studies have shown that severe ER stress is directly involved in the pancreatic β cells destruction and pathogenesis of T1D. ER stress plays a key part in pancreatic β cells and T1D, which will help in developing new effective therapeutics for T1D.
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