• British medical bulletin · Dec 2019

    Review

    The temporal effect of intra-articular ozone injections on pain in knee osteoarthritis.

    • Antonio Oliviero, Lorenzo Giordano, and Nicola Maffulli.
    • Department of Trauma and Orthopaedic Surgery, AOU San Giovanni di Dio e Ruggi D'Aragona, Via San Leonardo 1, 84131 Salerno, Italy.
    • Br. Med. Bull. 2019 Dec 11; 132 (1): 33-44.

    BackgroundOsteoarthritis (OA) is a most common orthopaedic condition, often complicated by inflammatory features.Sources Of DataA systematic search in PubMed, Embase, Google Scholar and Scopus databases (to January 2019) was performed to define the effect obtained in patients with OA of the knee by injections of ozone, on pain and physical function. Six RCTs and 353 patients were included.Areas Of AgreementRecently, an increasing number of physicians have used ozone therapy to alleviate the symptoms of acute and chronic OA of the knee. Ozone can allow greater mobility of the knee joint, pain relief and decrease in effusion.Areas Of ControversyThe volume and concentration of ozone injected are different in the various treatment protocols published.Growing PointsThe action of ozone is unclear, but it is a promising therapeutic modality capable of impacting, favourably, function and quality of life.Areas Timely For Developing ResearchThe lack of a clear protocol of use is a major limitation, and to date there is no clear evidence of long-term efficacy.© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…