• Lucio Cipollaro, Maria Camilla Ciardulli, Della PortaGiovannaGDepartment of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 Baronissi (SA), Italy., Giuseppe M Peretti, and Nicola Maffulli.
• Department of Musculoskeletal Disorders, Faculty of Medicine and Surgery, University of Salerno, Via San Leonardo 1, 84131 Salerno, Italy.
• Br. Med. Bull. 2019 Dec 11; 132 (1): 538053-80.

BackgroundGiven the limited regenerative capacity of injured articular cartilage, the absence of suitable therapeutic options has encouraged tissue-engineering approaches for its regeneration or replacement.Sources Of DataPublished articles in any language identified in PubMed and Scopus electronic databases up to August 2019 about the in vitro and in vivo properties of cartilage engineered constructs. A total of 64 articles were included following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Areas Of AgreementRegenerated cartilage lacks the biomechanical and biological properties of native articular cartilage.Areas Of ControversyThere are many different approaches about the development of the architecture and the composition of the scaffolds.Growing PointsNovel tissue engineering strategies focus on the development of cartilaginous biomimetic materials able to repair cartilage lesions in association to cell, trophic factors and gene therapies.Areas Timely For Developing ResearchA multi-layer design and a zonal organization of the constructs may lead to achieve cartilage regeneration.© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

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