• Samson Gebremedhin.
• School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia. Electronic address: samsongmgs@yahoo.com.
• Nutrition. 2020 Nov 1; 79-80: 110841.

ObjectivesSerum zinc negatively reacts to inflammation yet to our knowledge only a few studies have attempted to adjust it for inflammation. The aim of this study, based on the data of Malawi Micronutrient Survey, was to correct zinc concentration for inflammation in preschool children (n = 1081) and women of reproductive age (n = 799) and to evaluate the effects of the adjustment on the prevalence of zinc deficiency (ZD).MethodsBased on C-reactive protein (CRP) and α-1-acid glycoprotein (AGP), inflammation status was grouped into four categories: no inflammation, incubation, early convalescence, and late convalescence. The association between zinc and inflammation was examined using linear regression analysis and correction was made by six approaches: exclusion, internal correction factor, and four regression adjustments.ResultsThe unadjusted prevalence of ZD was 58.9% in children and 62% in women. Inflammation was observed in 57.6% of children and 17.1% of women. Zinc demonstrated negative correlations with inflammation markers (P < 0.05). Among children, zinc showed marginally insignificant (P = 0.072) decline during incubation (β= -8.25; 95% confidence interval [CI], -17.28 to 0.78) and significant decline during early convalescence inflammation (β= -4.92; 95% CI, -7.00 to -2.31). Among women, significant change was only observed in late convalescence inflammation (β= -4.10; 95% CI, -8.06 to -0.14). However, all the corrections resulted in modest decline in the prevalence of ZD (1.4-2.1 and 0-2.6 percentage points in children and women).ConclusionsThe study observed statistically significant negative correlations between serum zinc concentration and inflammation markers (AGP and CRP). However, correction of serum zinc for inflammation using multiple options including exclusion, internal correction factor, and regression adjustment resulted in very marginal changes in the prevalence of ZD. Although inflammation adjustment may enable more precise estimation of ZD, it only resulted in modest changes in the actual prevalence of ZD in Malawi.Copyright © 2020 Elsevier Inc. All rights reserved.

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