• Nutrition · Nov 2020

    Sex-specific effects of vegetarian diet on adiponectin levels and insulin sensitivity in healthy non-obese individuals.

    • Marijana Vučić Lovrenčić, Marko Gerić, Iva Košuta, Maro Dragičević, Vera Garaj-Vrhovac, and Goran Gajski.
    • Department of Clinical Chemistry and Laboratory Medicine, Merkur University Hospital, Zagreb, Croatia.
    • Nutrition. 2020 Nov 1; 79-80: 110862.

    ObjectivesThe beneficial influence of a vegetarian diet in reducing the risk for metabolic syndrome has been demonstrated. However, adiponectin production and secretion are scarcely studied in vegetarians, despite their important role in recovering metabolic homeostasis by reducing visceral obesity, inflammation, and insulin resistance. The aim of this study was to evaluate the effect of a vegetarian diet on serum adiponectin levels and its association with the established biomarkers of insulin sensitivity and inflammation in healthy, non-obese individuals.MethodsAdiponectin, C-reactive protein, uric acid, glucose, insulin, lymphocyte and polymorphonuclear cell counts were determined in the blood of sex- and age-matched healthy vegetarian (n = 40) and omnivore (n = 36) individuals. The homeostatic model assessment (HOMA-2) calculator was used for the β-cell function (HOMA2-%B) and insulin resistance index (HOMA2-IRI) estimation.ResultsAdiponectin levels were significantly higher in female vegetarians than the respective omnivore controls (P = 0.03), whereas no dietary-associated difference was observed in men. HOMA2-%B was significantly higher in vegetarians than in omnivore controls (P = 0.04), whereas no diet-dependent differences were found in insulin, HOMA2-IRI, inflammatory, and metabolic biomarkers. Multiple regression analysis showed that adiponectin levels were significantly predicted by the type of diet only in women (P = 0.042), whereas no associations were found in men.ConclusionsA vegetarian diet resulted in improved β-cell function. Favorable adiponectin and insulin sensitivity responses in women reveal a distinct effect of diet-to-metabolic homeostasis, indicating an interesting pattern of sexual dimorphism regarding the beneficial metabolic effect of a vegetarian diet.Copyright © 2020 Elsevier Inc. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…