• African health sciences · Dec 2019

    High risk human papilloma virus (HPV) common among a cohort of women with female genital mutilation.

    • Jeremiah Ogah, Olatunji Kolawole, and Daniel Awelimobor.
    • Infectious Diseases and Environmental Health Research Group, Department of Microbiology, University of Ilorin.
    • Afr Health Sci. 2019 Dec 1; 19 (4): 2985-2992.

    BackgroundNigeria accounts for 25% of cases of Female genital mutilation (FGM) worldwide, with increased incidence of cervical cancer.ObjectiveThis study was aimed at evaluating the relationship between FGM and HPV in a locality with high prevalence of FGM.MethodsPapanicolaou test, DNA hybridization using Polymerase Chain Reaction (PCR), and flow-through hybridization was done to determine the genotypic variants of the HPV. Physical examination and questionnaires were also used to ascertain presence of FGM.ResultsFGM was found among 98(49%) subjects, while 23(11.5%) had one or more genotype of HPV. Majority of the cases of HPV (78.3%) occurred in FGM subjects. Seventeen Genotypes of HPV were found among subjects with FGM consisting of 11 high risk (16, 18, 31, 33, 35, 39, 52, 56, 73, 81, 82) and 6 low risk (43, 44, 6, 26, 84, 70). A correlation (p value = 0.0052 at 95% CI) was found between FGM and HPV prevalence with a positive result for post hoc analysis. Results show the first reported case of quintuple HPV infection in a single subject in Nigeria.ConclusionFGM needs to be halted as it has no known health benefit yet may increase the risk for cervical cancer.© 2019 Ogah et al.

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