• Nutrition · Nov 2020

    Vitamin C as prophylaxis and adjunctive medical treatment for COVID-19?

    • Adam F Feyaerts and Walter Luyten.
    • VIB Center for Microbiology, KU Leuven, Leuven, Belgium; Laboratory of Molecular Cell Biology, KU Leuven, Leuven, Belgium; Department of Technology, UCLL, Leuven, Belgium. Electronic address: adamfeyaerts@gmail.be.
    • Nutrition. 2020 Nov 1; 79-80: 110948110948.

    AbstractSevere acute respiratory syndrome coronavirus 2 causes the potentially fatal coronavirus disease 2019 (COVID-19). Already during the outbreak of the severe acute respiratory syndrome coronavirus 1, the use of vitamin C was suggested. Many patients with severe COVID-19 have elevated levels of the mediators interleukin-6 and endothelin-1. These mediators may explain the age dependence of COVID-19 pneumonia, the preponderance of male and obese or hypertensive patients, as well as of persons of color and smokers. There is clear evidence that vitamin C in high doses can reduce these mediators. Vitamin C is cheap and safe. Hence, using a relatively low dose of vitamin C as prophylaxis, and in cases of severe COVID-19, an (intravenous) high-dose regimen may be beneficial. Ongoing clinical trials are expected to provide more definitive evidence.Copyright © 2020 Elsevier Inc. All rights reserved.

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