• Agata Tymińska, Agnieszka Kapłon-Cieślicka, Krzysztof Ozierański, Monika Budnik, Anna Wancerz, Piotr Sypień, Michał Peller, Jakub Maksym, Paweł Balsam, Grzegorz Opolski, and Krzysztof J Filipiak.
• 1st Department of Cardiology, Medical University of Warsaw, Warsaw, Poland
• Pol. Arch. Med. Wewn. 2019 Nov 29; 129 (11): 770-780.

IntroductionGalectin‑3 (Gal‑3) and soluble interleukin-1 receptor-like 1 (sST2) have known prognostic value in already diagnosed heart failure (HF).ObjectivesTo investigate the association of Gal‑3 and sST2 with prognosis in patients with ST‑segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI).Patients And MethodsThe analysis was based on data collected in a prospective observational BIOSTRAT (Biomarkers for Risk Stratification After STEMI; ClinicalTrials.gov identifier, NCT03735719) study. Analysis included 117 patients with first‑time STEMI treated with pPCI. Serum for Gal‑3 and sST2 was sampled 72 to 96 hours after admission due to STEMI. The patients were followed for the primary endpoint (cardiovascular [CV] death or HF hospitalization at 1 year).ResultsBoth biomarkers correlated with N‑terminal pro‑B‑type natriuretic peptide (NT‑proBNP); Gal‑3 correlated with older age. Data on the primary endpoint were available for 104 patients (89%). At 1‑year follow‑up, 9 patients (8.7%) reached the primary endpoint. In univariate Cox proportional hazards regression analysis, both Gal‑3 and sST2 as continuous variables, as well as their newly‑established cutoffs (≥9.57 ng/ml for Gal‑3 and ≥45.99 ng/ml for sST2, based on the Youden index) were predictors of the primary endpoint, and of HF hospitalizations alone. Gal‑3 also predicted CV death. After adjustment for age and NT‑proBNP, Gal‑3 and sST2 remained predictors of the primary endpoint in multivariate models.ConclusionsIn patients with first‑time STEMI treated with pPCI, baseline Gal‑3 and sST2 predicted the composite of CV death and HF hospitalization at 1 year. Both biomarkers may play an important role in CV risk stratification after STEMI, although Gal‑3 may be considered preferable.

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