• Magda Wiśniewska, Natalia Serwin, Violetta Dziedziejko, Małgorzata Marchelek-Myśliwiec, Barbara Dołęgowska, Leszek Domański, Kazimierz Ciechanowski, Krzysztof Safranow, and Andrzej Pawlik.
• Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
• Pol. Arch. Med. Wewn. 2019 Nov 29; 129 (11): 790797790-797.

IntroductionRenalase is a novel flavin adenine dinucleotide-dependent amine oxidase with catecholamine-degrading activity. The kidneys are the main source of this enzyme.ObjectivesIn this study, we examined the concentrations of renalase in the serum, urine, and erythrocytes of patients with chronic kidney disease (CKD).Patients And MethodsWe enrolled 155 white patients with CKD and 30 healthy controls. Renalase concentrations were measured using an enzyme‑linked immunosorbent assay.ResultsSerum renalase levels were higher in patients with CKD than in controls: median (Q1-Q3), 103 ng/ml (55.6-166 ng/ml) vs 17.7 ng/ml (16.3-21.8 ng/ml); P <0.001. Renalase levels in erythrocytes were lower in patients with CKD than in controls (median [Q1-Q3], 122 ng/ml [67.2-189 ng/ml] vs 254 ng/ml [166-293 ng/ml]; P <0.001). Urinary renalase levels did not differ between patients with CKD and controls (median [Q1-Q3], 147 ng/ml [102-193 ng/ml] vs 144 ng/ml [116-170 ng/ml]; P = 0.78). Urinary and erythrocyte renalase concentrations were negatively correlated with estimated glomerular filtration rate (eGFR). A multivariate general linear model analysis adjusted for age, sex, and eGFR of CKD patients showed that higher plasma dopamine and total protein concentrations were independent predictors of higher serum renalase levels (β = 0.32, P <0.001 and β = 0.25, P <0.001, respectively).ConclusionsOur results indicate that serum renalase concentrations are elevated in patients with CKD, whereas renalase concentrations in urine and erythrocytes are correlated with impaired kidney function.

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