• Akiko Shimada, Lene Baad-Hansen, Eduardo Castrillon, Bijar Ghafouri, Niclas Stensson, Björn Gerdle, Malin Ernberg, Brian Cairns, Peter Svensson, and Peter Svensson Odont.
• Section of Clinical Oral Physiology, Department of Dentistry, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark; Scandinavian Center for Orofacial Neurosciences (SCON). Electronic address: akiko.shimada@odontologi.au.dk.
• Nutrition. 2015 Feb 1;31(2):315-23.

ObjectiveThe aim of this study was to determine the relationship of high daily monosodium glutamate (MSG) consumption with glutamate concentrations in jaw muscle, saliva, and serum, and muscle pain sensitivity in healthy participants.MethodsA randomized, double-blinded, placebo-controlled study was conducted to investigate the effect of repetitive consumption of high-dose MSG on glutamate concentration in the masseter muscles measured by microdialysis and muscle pain sensitivity. In five contiguous experimental daily sessions, 32 healthy participants drank MSG (150 mg/kg) or NaCl (24 mg/kg) diluted with a 400 mL soda. The concentrations of glutamate before and after the ingestion were assessed in dialysate and plasma samples on the first and last days. Saliva glutamate concentration was assessed every day. Pressure pain threshold, pressure pain tolerance, autonomic parameters (heart rate, systolic and diastolic blood pressures) and reported side effects also were assessed.ResultsNo significant change was noted in the baseline concentration of glutamate in the masseter muscle, blood, or saliva, but the peak concentration in the masseter muscle increased significantly between day 1 and 5. A statistically significant increase in systolic and diastolic blood pressures after MSG administration was observed, as well as a significantly higher frequency of reports of nausea and headache in the MSG group. No robust effect of MSG on muscle sensitivity was found.ConclusionInterstitial glutamate concentration in the masseter muscle is not highly disturbed by excessive repetitive intake of MSG in healthy man.Copyright © 2015 Elsevier Inc. All rights reserved.

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