• Olayemi Olubunmi Dawodu, Kehinde Sharafadeen Okunade, Adetola Daramola, and Adekunbiola Aina Fehintola Banjo.
• Department of Anatomic and Molecular Pathology, College of Medicine, University of Lagos.
• Afr Health Sci. 2019 Sep 1; 19 (3): 2468-2475.

BackgroundCategorization of endometrial carcinomas as type I and II provides useful insights into their different risk factors, pathogenesis and biologic behaviours.AimTo determine the immunohistochemical classifications of endometrial carcinomas in Nigerian women.DesignA retrospective review of histopathologic slides of cases of endometrial carcinomas seen at the Lagos University Teaching Hospital (LUTH) over a 5-year period. The slides were reviewed, and the diagnoses made according to the WHO nomenclature. The classification of endometrial carcinomas into Type I and II was made by immunohistochemistry using antibodies to ER, PR, p53 and Ki-67.ResultsEight cases of endometrial adenocarcinoma were reported accounting for 53.3% of all endometrial malignancies. Of these, only 1 case showed the classic type I immunophenotype while type II staining pattern was seen in 4 cases. The remaining 3 cases had equivocal immunophenotypes: one was p53+ but showed ER+, PR+ and high Ki-67 index; the second was p53-, ER+, PR+ but had a high Ki-67 expression; while the last was p53-, but ER-, PR- and had high Ki-67 expression.ConclusionEndometrial carcinomas in Nigerian women are more likely to be type II carcinomas. A reasonable proportion of the cases were equivocal thus requiring further categorization with molecular studies.© 2019 Dawodu et al.

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