• Osita U Ezenwosu, Barth F Chukwu, Okechukwu C Okafor, Anthony N Ikefuna, and Ifeoma J Emodi.
• Department of Paediatrics, University of Nigeria, Enugu Campus, Enugu, Nigeria.
• Afr Health Sci. 2019 Dec 1; 19 (4): 324932523249-3252.

IntroductionBurkitt Lymphoma is the fastest growing tumor in human and the commonest of the childhood malignancies. Generalized lymphadenopathy is a common feature of immunodeficiency associated Burkitt lymphoma but an uncommon presentation of the endemic type in Human Immunodeficiency Virus (HIV) negative children.Case PresentationThe authors report a 6 year old HIV negative boy who presented with generalized lymphadenopathy, cough, weight loss, fever and drenching night sweat and had received native medication as well as treatment in private hospitals. His examination revealed hepatosplenomegaly, bull neck with generalized significant massive lymphadenopathy. Diagnosis was missed initially until a lymphnode biopsy for histology confirmed Burkitt lymphoma. He was managed on combination chemotherapy with complete resolution and now on follow up.ConclusionTo the best of our knowledge, this is the first documented report of its kind of endemic Burkitt lymphoma involving lymphnodes generally as the primary site. High index of suspicion and early biopsy are the key in this uncommon presentation.© 2019 Ezenwosu et al.

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