• Lilia Castillo-Martínez, Eloisa Colín-Ramírez, Arturo Orea-Tejeda, Dulce Gabriela González Islas, Wendy Daniella Rodríguez García, Cira Santillán Díaz, Ana Elizabeth Gutiérrez Rodríguez, Marisela Vázquez Durán, and Candace Keirns Davies.
• Heart Failure Clinic, Cardiology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Del Valle, Benito Juárez CP, Mexico.
• Nutrition. 2012 Sep 1;28(9):886-91.

BackgroundThis study explored whether the cachectic state assessed by bioimpedance vector analysis provides additional prognostic information about mortality from all causes.MethodsWe included 519 consecutive patients with stable chronic heart failure (mean age 62.5 ± 16.4 y; 286 males). Cachexia was identified in those subjects who fell outside the right lower quadrant of the reference curve of 95% on the resistance/reactance graph [bioelectrical impedance vectorial analysis (BIVA)-cachexia]. Clinical, anthropometric, and biochemical data were also evaluated.ResultsPatients with BIVA-cachexia (n = 196, 37.8%) were older and had significantly lower ejection fraction, handgrip strength, serum albumin, total cholesterol, and triglycerides. The frequency of patients with body mass index < 20, decreased muscle strength, hypoalbuminemia, anemia, anorexia, New York Heart Association functional classes III/IV and edema, as well as creatinine levels, resistance/height, and impedance index was significantly higher in the cachexia group. During 29 ± 11 mo of follow-up, 39 (19.9%) patients with BIVA-cachexia and 38 (11.7%) patients without BIVA-cachexia (P < 0.0001) died.ConclusionsThe cachectic state is an independent risk factor for mortality in chronic heart failure patients. BIVA could represent a valuable tool to assess presence of cachexia as changes in body cell mass in heart failure patients because provide information additional to weight loss.Copyright © 2012 Elsevier Inc. All rights reserved.

34 keywords...

hide…