• Fei Qi, Yong Li, Xue Yang, Yan-Ping Wu, Lian-Jun Lin, and Xin-Min Liu.
• Department of Geriatrics, Peking University First Hospital, Peking University, Beijing 100034, China.
• Chin. Med. J. 2020 Jan 20; 133 (2): 221-228.

ObjectiveAlternative splicing can generate various structural and functional protein isoforms. Recently, accumulating evidence shows a relationship between alternative splicing and cancer. Cancer is a complex and chronic disease that involves malignant transformation. In this review, we consider alternative splicing events in relation to the hallmarks of cancer cells, and discuss current therapies to treat cancer-related to alternative splicing.Data SourcesData cited in this article are from the PubMed and Embase database, primarily focusing on research published from 2000 to 2018.Study SelectionArticles were selected with the search terms "alternative splicing," "cancer cell," "tumor microenvironment," and "therapy."ResultsAlternative splicing plays an important role in tumorigenesis, development, and escape from cell death. Taking this trait of cancer cells into consideration will allow more definite diagnoses of cancer, and allow the development of more effective medicines to intervene in cancer that could focus on controlling alternative splicing or competitively binding to the final products.ConclusionsAlternative splicing is common in cancer cells. Consideration of alternative splicing may allow different strategies for cancer therapy or the identification of novel biomarkers for cancer diagnosis.

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