• Arch Med Sci · Sep 2019

    Antisense of survivin inhibits cervical cancer growth in mice.

    • Hui Xu, Tingting Liang, Yongxia Yang, Yanlei Dong, and Lin Zhu.
    • Department of Gynecology, the Second Hospital, Shandong University, Jinan, China.
    • Arch Med Sci. 2019 Sep 1; 15 (5): 1345-1351.

    IntroductionIt is proposed that survivin plays a critical role in the pathogenesis of cancer. Immune regulatory cells are associated with the growth of cancer in the body. Antisenses for the key molecules can suppress tumor growth. This study tests the hypothesis that the antisense of survivin can inhibit cervical cancer.ResultsThe results showed that human cervical cancer cells expressed high levels of survivin. The levels of survivin in cervical cancer positively correlated with the frequency of interleukin (IL)-10-producing B cells (B10 cells) in the cancer tissue. Survivin increased the expression of IL-10 in B cells. Exposure to survivin antisense efficiently decreased IL-10 expression in B cells. Administration of antisense of survivin inhibited cervical cancer growth and reduced the frequency of B10 cells in tumor-bearing mice.ConclusionsThe results suggest that the survivin antisense has the potential to be used in the treatment of cervical cancer.Copyright: © 2017 Termedia & Banach.

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