• Aleksandra Klisic, Nebojsa Kavaric, Verica Stanisic, Sanja Vujcic, Vesna Spasojevic-Kalimanovska, Ana Ninic, and Jelena Kotur-Stevuljevic.
• Center of Laboratory Diagnostics, Primary Health Care Center, Podgorica, Montenegro.
• Arch Med Sci. 2020 Jan 1; 16 (1): 425042-50.

IntroductionWe aimed to examine serum endocan level and the summary involvement of dyslipidemia, oxidative stress (OS) and inflammation by calculation of its comprehensive score (i.e. Dyslipidemia-Oxy-Inflammation (DOI) score) in relation to glucoregulation in subjects with prediabetes and overt type 2 diabetes (T2D).Material And MethodsA total of 59 patients with prediabetes and 102 patients with T2D were compared with 117 diabetes-free controls. Glycated hemoglobin (HbA1c), inflammation, OS and lipid parameters were measured. Associations of clinical data with HbA1c level were tested with univariate and multivariate logistic ordinal regression analysis. HbA1c as a dependent variable is given at the ordinal level (i.e. < 5.7%; 5.7-6.4%, > 6.4%, respectively).ResultsEndocan was significantly higher in the T2D group than in the controls. As endocan concentration rose by 1 unit, the probability for higher HbA1c concentration increased by more than 3 times (OR = 3.69, 95% CI: 1.84-7.01, p < 0.001). Also, a rise in the dyslipidemia score, oxy score, inflammation score and DOI score by 1 unit increased the probability of higher HbA1c concentration by 19%, 13%, 51% and 11%, respectively. In the models, after adjustment for confounding variables, endocan and DOI score remained independent predictors of HbA1c level.ConclusionsEndocan and DOI score are independently correlated with HbA1c in patients with prediabetes and overt T2D.Copyright: © 2019 Termedia & Banach.

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