• Dirk Dannenberger, Gerd Nuernberg, Ulla Renne, Karin Nuernberg, Martina Langhammer, Korinna Huber, and Bernhard Breier.
• Department of Muscle Biology and Growth, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany. dannenberger@fbn-dummerstorf.de
• Nutrition. 2013 May 1;29(5):765-71.

ObjectiveThe aim of the study is to determine the response of muscle lipid peroxidation and the fatty-acid profile of three groups of mice-high body weight (DU6) obesity-prone mice, high treadmill performance (DUhTP) lean mice, and unselected control mice (DUK) fed high-fat diets (HFDs) rich in ω-3 or ω-6 polyunsaturated fatty acids (PUFA).MethodsThe isocaloric HFDs were enriched with either ω-3 PUFA (27% fish oil, ω-3 HFD) or ω-6 PUFA (27% sunflower oil, ω-6 HFD), and the control group was fed standard chow (7.2% fat). Statistical calculations were done with procedure GLM of SAS.ResultsAs expected, the ω-3 and ω-6 PUFA-rich HFDs showed significant effects on fatty-acid concentrations of skeletal muscle in all three lines of mice compared with the standard chow. The investigations of muscle lipid peroxidation revealed that the ω-3 PUFA-rich HFD caused the highest lipid peroxidation values in muscle of lean DUhTP mice and unselected control DUK mice. However, lower lipid peroxidation levels were observed in the obesity-prone DU6 mice. In contrast, the ω-6 PUFA-rich HFD did not influence lipid peroxidation in muscle of any of the different lines of mice. The present study suggests that a higher overall antioxidant capacity in the muscle tissue of obesity-prone DU6 mice may lead to lower levels of reactive oxygen species formation by ω-3 PUFA-rich HFDs in comparison with lean DUhTP mice.ConclusionThese studies raise the possibility that obesity per se may be protective against oxidative damage when high ω-3 PUFA diets are used.Copyright © 2013 Elsevier Inc. All rights reserved.

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