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- CiarÁn E Fealy, Anny Mulya, Christopher L Axelrod, and John P Kirwan.
- Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
- Transl Res. 2018 Dec 1; 202: 69-82.
AbstractThe traditional view of mitochondria as isolated, spherical, energy producing organelles, is undergoing a revolutionary change. Emerging data show that mitochondria form a dynamic reticulum that is regulated by cycles of fission and fusion. The discovery of proteins that modulate these activities has led to important advances in understanding human disease. Here, we review the latest evidence that connects the emerging field of mitochondrial dynamics to skeletal muscle insulin resistance and propose some potential mechanisms that may explain the long debated link between mitochondria and the development of type 2 diabetes.Copyright © 2018. Published by Elsevier Inc.
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