• Methods Mol. Biol. · Jan 2017

    Measuring Direct Oral Anticoagulants.

    • Robert C Gosselin and Jonathan Douxfils.
    • Department of Pathology and Laboratory Medicine, Davis Health System, University of California, 4400 V Street, Sacramento, CA, 95817, USA. rcgosselin@outlook.com.
    • Methods Mol. Biol. 2017 Jan 1; 1646: 217-225.

    AbstractDirect oral anticoagulants (DOACs) can be quantified using methods that can be performed in any clinical or research laboratory using manual or automated instrument platforms. Dabigatran etexilate, the oral direct thrombin inhibitor, can be quantified by drug-calibrated clot or chromogenic-based assays using either thrombin or ecarin as substrates. Oral direct anti-Xa inhibitors, such as rivaroxaban, apixaban, and edoxaban, can be quantified with drug-calibrated anti-Xa kits or reagents as typically used for measuring heparins (unfractionated, low molecular weight, or pentasaccharides).

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