• Arch Med Sci · Jan 2020

    Changes in circulating stem cells and endothelial progenitor cells over a 12-month period after implantation of a continuous-flow left ventricular assist device.

    • Peter Ivak, Ivan Netuka, Ivana Kralova-Lesna, Peter Wohlfahrt, and Jan Pitha.
    • Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
    • Arch Med Sci. 2020 Jan 1; 16 (6): 1440-1443.

    IntroductionChanges in circulating CD34+CD45low stem cells (SC) and CD34+CD45low+KDR+ endothelial progenitor cells (EPC) may reflect pathological endothelial activation. Non-pulsatile/continuous-flow left ventricular assist devices (CF-LVAD) can enhance this process. The aim of this study was to analyse the impact of 12-month CF-LVAD treatment on SC and EPC.MethodsWe analysed changes in SC and EPC from the pre-implantation period up until 12 months after implantation over 3-month intervals in 14 patients. Data from 12 patients with heart failure (HF) and from 13 healthy volunteers were used as controls.ResultsBaseline EPC were significantly higher in CF-LVAD and HF patients than in healthy controls, substantially decreasing 3 months after CF-LVAD implantation and then returning to high baseline values at 12 months.ConclusionsChanges in circulating SC and EPC may reflect pathological endothelial activation after CF-LVAD implantation.Copyright: © 2020 Termedia & Banach.

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