• Sha Peng, Zhuang Peng, Meng Qin, Lu Huang, Bin Zhao, Lai Wei, Jie Ning, Qin-Hui Tuo, Ti-Fei Yuan, Zhe Shi, and Duan-Fang Liao.
• Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Hunan, China.
• Nutrition. 2021 Mar 1; 83: 111058.

AbstractSubstance abuse is a chronic relapsing disorder that results in serious health and socioeconomic issues worldwide. Addictive drugs induce long-lasting morphologic and functional changes in brain circuits and account for the formation of compulsive drug-seeking and drug-taking behaviors. Yet, there remains a lack of reliable therapy. In recent years, accumulating evidence indicated that neuroinflammation was implicated in the development of drug addiction. Findings from both our and other laboratories suggest that ω-3 polyunsaturated fatty acids (PUFAs) are effective in treating neuroinflammation-related mental diseases, and indicate that they could exert positive effects in treating drug addiction. Thus, in the present review, we summarized and evaluated recently published articles reporting the neuroinflammation mechanism in drug addiction and the immune regulatory ability of ω-3 PUFAs. We also sought to identify some of the challenges ahead in the translation of ω-3 PUFAs into addiction treatment.Copyright © 2020 Elsevier Inc. All rights reserved.

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