• J Coll Physicians Surg Pak · Dec 2020

    Van Wyk Grumbach Syndrome.

    • Maira Riaz, Mohsina Noor Ibrahim, Taj Muhammad Laghari, Misbah Iqbal Hanif, and Jamal Raza.
    • Department of Paediatrics, National Institute of Child Health, Karachi, Pakistan.
    • J Coll Physicians Surg Pak. 2020 Dec 1; 30 (12): 1332-1334.

    AbstractVan Wyk Grumbach syndrome is well known for protracted hypothyroidism, characterised by multicystic ovaries (normal size ovaries contain many follicles of various sizes), isosexual precocious puberty and delayed skeletal growth. A series of ten children with Van Wyk Grumbach syndrome is been presented with their clinical features, biochemical and radiological profile and management. Patients showed a noteworthy improvement upon thyroxine therapy. It is vital to keep this entity in consideration and; hence, should investigate for thyroid status during the evaluation of ovarian cysts. Thyroxin replacement after establishing the diagnosis early can prevent the patient from going through extensive workup and surgeries. Key Words: Hypothyrodism, Multicystic ovaries, Isosexual precocious puberty.

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