Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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J Coll Physicians Surg Pak · Dec 2020
Diagnostic Value of Serum Gastrin and Epidermal Growth Factor to the Gastric Ulcer Complicated with Upper Gastrointestinal Hemorrhage.
To explore the predictive value of serum gastrin (GAS), epidermal growth factor (EGF) levels in gastric ulcer complicated with acute upper gastrointestinal bleeding. ⋯ The predictive value of serum GAS and EGF is high for gastric ulcer complicated with acute upper gastrointestinal bleeding; the predictive value of serum EGF is greater than that of serum GAS. Key Words: Gastric ulcer, Acute upper gastrointestinal bleeding, Serum, Gastrin (GAS), Epidermal growth factor (EGF), Logistic regression, Receiver operating characteristic (ROC) curve.
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Van Wyk Grumbach syndrome is well known for protracted hypothyroidism, characterised by multicystic ovaries (normal size ovaries contain many follicles of various sizes), isosexual precocious puberty and delayed skeletal growth. A series of ten children with Van Wyk Grumbach syndrome is been presented with their clinical features, biochemical and radiological profile and management. ⋯ Thyroxin replacement after establishing the diagnosis early can prevent the patient from going through extensive workup and surgeries. Key Words: Hypothyrodism, Multicystic ovaries, Isosexual precocious puberty.
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J Coll Physicians Surg Pak · Dec 2020
Meta AnalysisMeta-analysis of the Value of Cardiac Nuclear Magnetic Resonance in the Diagnosis of Viral Myocarditis.
To evaluate the diagnostic value of cardiac magnetic resonance imaging (MRI) in viral myocarditis by meta-analysis. PubMed, EMbase, Cochrane, Web of Science, China National Knowledge Infrastructure (CNKI, China) Wanfang Databases were searched for clinical research literature on MRI diagnosis of viral myocarditis from the establishment of the database to March 1, 2020. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio (DOR) and the summary receiver operating characteristic (SROC) were analysed by Stata 15.0. ⋯ Existing research have confirmed that cardiac MRI has high sensitivity (94%) and moderate specificity (75%) for viral myocarditis. The positive ratio of test in myocarditis group is 45.24 times higher than that in non-myocarditis group indicating the outstanding effect of diagnosis and discrimination. Key Words: Cardiac magnetic resonance imaging, Viral myocarditis, Systematic review, Meta-analysis.
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J Coll Physicians Surg Pak · Dec 2020
Tissue Nuclear Matrix Protein Expression 22 in Various Grades and Stages of Bladder Cancer.
To study the tissue nuclear matrix protein 22 (NMP22) expression in bladder carcinoma biopsy and correlate it with prognostic factors like stage and grade of bladder cancer. ⋯ A total of 95 paraffin blocks of bladder carcinoma biopsies with data were retrieved for the study. NMP22 was expressed immunohistochemically in 87/95(91.6%) of cases and was negative in 8/95(8.4%) of cancers. Correlation of intensity of NMP22 staining with histologic grade showed that 58.3% of high grade BC expressed NMP22 strongly, 23.6% moderately and 11.1% weakly. In low grade tumors, no biopsy (0/23) expressed strong expression. Moderate intensity in 8.69% and weak in 78.26% of tumors (p<0.001). Intensity of staining with stage of tumor association revealed that 40.8% of stage I tumor showed strong staining, 16.9% moderate, and 32.3% weak staining pattern. In stage II tumors 54.1% showed strong, 29.1% moderate, and 12.5% weak NMP 22 expression. (p=0.148). Conclusion: NMP 22 is highly expressed in urinary bladder carcinoma and in male patients. It has strong association with grade and weak association with stage of tumor. Immunohistochemical expression of this protein can help in better detection and prognostic prediction of bladder carcinoma. Key Words: Bladder carcinoma, Grade, Immunohistochemistry, NMP22, Stage.
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J Coll Physicians Surg Pak · Dec 2020
Perioperative Indices Predicting Fever Following Percutaneus Nephrolithotomy.
To investigate 18 independent peroperative parameters that may have an effect on fever after percutaneous nephrolithotomy (PCNL). ⋯ High GSS, mid-calyceal access, the increase in the amount of mid-calyceal access, the longer duration of achieving limpid urine coming out of the nephrostomy tube were found to be related with fever after PCNL. Key Words: PCNL, Post-PCNL fever, Nephrolithiasis, Guy's stone score.