• Nutrition · Jun 2021

    Micronutrient supplementation needs more attention in patients with refractory epilepsy under ketogenic diet treatment.

    • Mariana Baldini Prudencio, de Lima Patricia Azevedo PA Program in Applied Human Nutrition, Faculty of Pharmacy, University of São Paulo, São Paulo, Brazil., Daniela Kawamoto Murakami, Sampaio Leticia Pereira de Brito LPB Children's Institute, Hospital of Clinics, School of Medicine, University of São Paulo, São Paulo, Brazil., and Damasceno Nágila Raquel Teixeira NRT Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil. Electronic address: nagila@usp.br..
    • Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil.
    • Nutrition. 2021 Jun 1; 86: 111158.

    ObjectivesThis study evaluated the adequacy of micronutrient intake from the ketogenic diet (KD) with and without micronutrient supplementation according to age in Brazilian children and adolescents with refractory epilepsy undergoing KD treatment.MethodsThis study enrolled children and adolescents with refractory epilepsy who were up to 19 y of age. Nutrient intakes were monitored using 3 d food records before introducing micronutrient supplementation and 3 mo after starting KD treatment. The prevalence of micronutrient inadequacy was estimated by sex and age according to the estimated average requirement cutoff values.ResultsThis study included 39 children and adolescents. The KD did not provide enough content of folate, calcium, and magnesium in all patients according to the dietary reference intake. Even after starting supplementation, calcium, phosphorus, and magnesium intake remained inadequate in the majority of patients. The supplementation effectively met the vitamin B12 recommendation in all age groups.ConclusionsKD treatment did not provide adequate levels of the monitored micronutrients. The supplementation improved but did not prevent the inadequacy of micronutrients such as calcium, magnesium, and phosphorus. The results highlight the importance of individual supplementation protocols and the need to monitor micronutrient intake according to age and sex.Copyright © 2021. Published by Elsevier Inc.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…