• Ibrahim Ethem Ozsoy, Mehmet Akif Tezcan, Seda Guzeldag, and Ayse Turunc Ozdemir.
• Department of Thoracic Surgery, Kayseri Health Practice and Research Centre, University of Health Sciences, Turkey.
• J Coll Physicians Surg Pak. 2021 Feb 1; 31 (2): 132-137.

ObjectiveTo determine the risk factors for spontaneous pneumomediastinum (SPM), its clinical course and effect on prognosis in patients with Coronavirus disease-19 (COVID-19) pneumonia.Study DesignDescriptive study.Place And Duration Of StudyKayseri City Training and Research Hospital, Turkey, from April  to September 2020.MethodologyAll COVID-19 patients' clinical, laboratory, and radiologic characteristics, as well as treatment outcome data, were obtained through medical record extraction. Group A had 50 patients (22 men and 28 women) without SPM, and Group B had 20 patients (10 men and 10 women) with SPM.ResultsConsidering the accompanying comorbidities, the frequencies of asthma and inhaler-use was significantly higher in Group B than in Group A (p <0.05). In the CT evaluation at presentation, the rate of involvement of all five lobes of the lung in Group B was significantly higher than in Group A. Rates of tube thoracostomy, mechanical ventilator requirement, length of stay in hospital, and exitus were significantly higher in Group B than in Group A (p <0.05).ConclusionSPM development in a patient with COVID-19 pneumonia is a sign that the prognosis will not be good, and these patients need a more aggressive treatment. Key Words: Spontaneous pneumomediastinum, COVİD-19, Pneumothorax, Real-time polymerase chain reaction, Subcutaneous emphysema.

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