• J Coll Physicians Surg Pak · Feb 2021

    Case Reports

    Acute Hepatitis-A Virus Infection as a Rare Cause of Hemophagocytic Lymphohistiocytosis.

    • Ali Dogan, Sinan Demircioglu, and Omer Ekinci.
    • Department of Hematology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.
    • J Coll Physicians Surg Pak. 2021 Feb 1; 31 (2): 232-234.

    AbstractHemophagocytic lymphohistiocytosis (HLH) is a rare disorder of the mononuclear phagocytic system, characterised by histiocyte and lymphocyte activation. It can be classified as primary and secondary HLH. Primary HLH usually presents in childhood, and is associated with gene mutations. Secondary HLH usually presents in adulthood, and is due to an underlying infection, autoimmune disease or malignancy. We describe a case of HLH secondary to acute hepatitis-A virus infection, which was characterised by persistent fever, pancytopenia, splenomegaly, hyperferritinemia, and hemophagocytosis observed in the bone marrow. Key Words: Hemophagocytic lymphohistiocytosis, Hepatitis-A, Mononuclear phagocytes.

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