• Elis C S Fatel, Flávia T Rosa, Daniela F Alfieri, Tamires Flauzino, Bruna M Scavuzzi, Marcell A B Lozovoy, Tatiana M V Iriyoda, Simão Andréa N C ANC Department of Pathology, Clinical Analysis and Toxicology, Universidade Estadual de Londrina, Londrina, Brazil., and Isaias Dichi.
• Health Science Graduate Program, Universidade Estadual de Londrina, Londrina, Brazil.
• Nutrition. 2021 Jun 1; 86: 111183.

ObjectivesWe sought to determine whether cranberry juice consumption would ameliorate laboratory and clinical measurements of disease activity in people with rheumatoid arthritis receiving fish oil supplementation.MethodsA prospective study was performed with 62 people with rheumatoid arthritis. We analyzed C-reactive protein modification of the Disease Activity Score-28 (DAS28-CRP) and inflammatory markers. The first group was assigned to eat their typical diet, a second group was asked to consume 3 g of fish oil ω-3 fatty acids daily, and a third group received both 3 g of fish oil n-3 fatty acids and 500 mL of reduced-calorie cranberry juice daily.ResultsCompared with baseline values, the group receiving both fish oil and cranberry juice showed reductions in erythrocyte sedimentation rate (P = 0.033), C-reactive protein (P = 0.002), DAS28-CRP (P = 0.001), adiponectin (P = 0.021), and interleukin-6 levels (P = 0.045), whereas the fish oil group showed decreased DAS28-CRP (P = 0.0261) and adiponectin (P = 0.0239). Differences across treatments showed that the group receiving both fish oil and cranberry experienced reductions (P < 0.05) in erythrocyte sedimentation rate and C-reactive protein compared to the control group and the group treated with fish oil alone, and a reduction in DAS28-CRP was verified when the fish oil and cranberry group was compared to the control group.ConclusionsThe ingestion of cranberry juice adds beneficial effects to fish oil supplementation, decreasing disease activity and inflammatory biomarkers in people with rheumatoid arthritis.Copyright © 2021 Elsevier Inc. All rights reserved.

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