• Natalie Slopen, Ying Chen, Naomi Priest, Michelle A Albert, and David R Williams.
• Department of Epidemiology and Biostatistics, School of Public Health, University of Maryland College Park, United States. Electronic address: nslopen@umd.edu.
• Prev Med. 2016 Mar 1; 84: 909690-6.

ObjectiveTo determine whether greater emotional and instrumental support during childhood is associated with less dysregulation across multiple physiological systems in midlife.MethodsData are from participants in the second wave of the Midlife in the United States study (2004-2005) who participated in a clinic-based assessment of health status. Emotional and instrumental support was measured using a seven-item scale (α=0.89) based on participant retrospective self-report. Biological dysregulation was assessed using an allostatic load (AL) score constructed from 24 measures across seven physiological systems (N=1236, aged 34-84 years).ResultsEmotional and instrumental support in childhood was associated with lower AL in a monotonic fashion: compared to individuals in the lowest quartile of support, respondents in the second, third, and fourth quartiles had -0.08 (standard deviation (SD)=0.08), -0.13 (SD=0.08) and -0.21 (SD=0.08) units lower AL, adjusting for age, sex, and race. This pattern was maintained after adjustment for reporting bias, childhood socioeconomic disadvantage, past-year depression, and physician-diagnosed cardiovascular disease or diabetes (p≤0.01). The inflammation and metabolic-lipid subscales showed the strongest associations.ConclusionsGreater emotional and instrumental support in childhood was associated with less biological dysregulation in midlife, even after accounting for socioeconomic disadvantage in childhood and other potential confounders.Copyright © 2015 Elsevier Inc. All rights reserved.

25 keywords...

hide…