• A-M Vitikainen, P Lioumis, R Paetau, E Salli, S Komssi, L Metsähonkala, A Paetau, D Kicić, G Blomstedt, L Valanne, J P Mäkelä, and E Gaily.
• HUSLAB BioMag Laboratory, Hospital District of Helsinki and Uusimaa, Helsinki University Central Hospital, P.O. Box 340, FI-00029 HUS, Finland. anne-mari.vitikainen@helsinki.fi
• Neuroimage. 2009 Apr 1; 45 (2): 342-8.

AbstractInvasive cortical mapping is conventionally required for preoperative identification of epileptogenic and eloquent cortical regions before epilepsy surgery. The decision on the extent and exact location of the resection is always demanding and multimodal approach is desired for added certainty. The present study describes two non-invasive preoperative protocols, used in addition to the normal preoperative work-up for localization of the epileptogenic and sensorimotor cortical regions, in two young patients with epilepsy. Magnetoencephalography (MEG) was used to determine the primary somatosensory cortex (S1) and the ictal onset zones. Navigated transcranial magnetic stimulation (nTMS) was used to determine the location and the extent of the primary motor representation areas. The localization results from these non-invasive methods were used for guiding the subdural grid deployment and later compared with the results from electrical cortical stimulation (ECS) via subdural grids, and validated by surgery outcome. The results from MEG and nTMS localizations were consistent with the ECS results and provided improved spatial precision. Consistent results of our study suggest that these non-invasive methods can be added to the standard preoperative work-up and may even hold a potential to replace the ECS in a subgroup of patients with epilepsy who have the suspected epileptogenic zone near the sensorimotor cortex and seizures frequent enough for ictal MEG.

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