• Acta Neurol. Scand. · Sep 1977

    Clinical Trial Controlled Clinical Trial

    Bromocriptine versus placebo in levodopa treated patients with Parkinson's disease.

    • U Gron.
    • Acta Neurol. Scand. 1977 Sep 1; 56 (3): 269-73.

    AbstractTwenty patients with idiopathic parkinsonism who had been on optimal levodopa therapy for at least 3 months prior to the investigation and where effect of the treatment was decreasing or side effects were increasing, were treated with bromocriptine in a double-blind crossover trial during a 12 + 12 weeks period. Reduction in disability scores was found significant. Hyperkinesia was more frequent in the bromocriptine period than in the placebo period, but reduction of dose in six patients for this reason was not followed by deterioration. Both hyperkinesia and other side effects disappeared after dose reduction. Doses were 2.5 mg-40 mg. Bromocriptine seems a valuable supplement to previous therapy in these patients.

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