• Methods Mol. Biol. · Jan 2020

    Genome Sequencing in Esophageal Squamous Cell Carcinoma.

    • Suja Pillai, Neven Maksemous, and Alfred K Lam.
    • School of Biomedical Science, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.
    • Methods Mol. Biol. 2020 Jan 1; 2129: 217-240.

    AbstractTechnological advances in the form of next-generation sequencing allow sequencing of large numbers of different DNA sequences in a single/parallel reaction compared to conventional sequencing. It is a powerful tool which has enabled comprehensive characterization of esophageal squamous cell carcinoma. Whole-genome sequencing is the most comprehensive but expensive, whereas whole-exome sequencing is cost-effective, but it only works for the known genes. Thus, second-generation sequencing methods can provide a complete picture of the esophageal squamous cell carcinoma genome by detecting and discovering different type of alterations in the cancer which may lead to the development of effective diagnostic and therapeutic approaches for esophageal squamous cell carcinoma.

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